Neurotrophic factors to restore dopaminergic terminals in Parkinson’s disease: A viral vector-delivered genetic therapy

MDS Podcast Neurotrophic factors to restore dopaminergic terminals in Parkinson’s disease: A viral vector-delivered genetic therapy

Could gene therapy with neurotrophic factors help restore dopaminergic terminals in Parkinson’s disease? Dr. Michele Matarazzo speaks with Dr. Amber Van Laar about her team’s Phase 1b trial of AAV2–GDNF gene therapy delivered directly to the putamen. They discuss the preclinical evidence for GDNF, how advanced delivery techniques and higher putamen coverage may overcome past challenges,…

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