Podcast: MDS PODCAST: Defining Parkinson's disease

MDS Podcast Deep brain stimulation in Parkinson’s disease with cognitive impairment: real-world evidence

Deep brain stimulation (DBS) has long been considered a risky procedure for people with Parkinson’s disease and cognitive impairment. In this interview, Dr. Miocinovic presents real-world data, showing that DBS might be safe and useful in carefully selected patients with moderate cognitive impairment. Read the article.

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MDS Podcast History of Movement Disorders: The Finding of Alpha-Synuclein and Lewy Bodies

In this History of Movement Disorders Special Episode, Prof. Tiago Outeiro interviews Prof. Maria Grazia Spillantini about integral work involved in discovering the role alpha-synuclein plays in the development of Lewy bodies. She discusses where the field is now and what questions young researchers should start asking.

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MDS Podcast Hot topic: The gut microbiome in Parkinson’s

In this special Hot Topics episode, Dr. Filip Scheperjans discusses what we know and what we don’t yet know about the gut microbiome in Parkinson’s disease, theories of influencing pathways within the gut-brain axis, and future directions for exploring and altering the gut microbiome in this patient population to impact disease.

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MDS Podcast Pathological Validation of 2022 MSA Criteria

Sara Schaefer discusses with Dr. Eduardo de Pablo-Fernandez his recent paper in Movement Disorders providing retrospective pathological validation of the 2022 MDS MSA Criteria using specimens from the Queens Square Brain Bank. Read the article.

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MDS Podcast Walking through the falls: understanding gait with wearable sensors in Parkinson’s disease

In this paper, Dr. Vrustangkumar Shah and colleagues evaluated gait in patients with Parkinson’s disease in the lab and in real life, with and without levodopa through wearable sensors. Some measures are able to discriminate fallers from non-fallers in PD. Read the article.

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MDS Podcast Targeting alpha synuclein in early Parkinson’s disease. Clinical trials and future perspectives

Two clinical trials with antibodies targeting alpha synuclein in early Parkinson’s disease have been published in the New England Journal of Medicine. Anthony Lang and Gennaro Pagano, the first authors of the articles share the results and discuss the possible future perspectives with the MDS Podcast editor, Michele Matarazzo. Read the prasinezumab article. Read the…

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MDS Podcast Machine learning for drug repurposing: A novel approach to find new treatments for Parkinson’s disease

Dr. Matarazzo interviews Émeline Courtois about the recently published article on machine learning approach to discover marketed drugs that could have an impact on the development of Parkinson’s disease. Interestingly, furosemide and adrenergic drugs showed a potential protective effect in this very large cohort. Journal CME is available until January 19, 2024 Read the article.

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