Podcast: MDS PODCAST: Defining Parkinson's disease

MDS Podcast Neurovascular health and Lewy body disorders, where is the connection?

Studies have shown a close interplay between the cerebrovascular system and neurodegeneration. But what is the current evidence, and how can it help us better understand the pathophysiology of Lewy body disorders and potentially change their course? In this episode, Dr. Michele Matarazzo interviews Prof. Sephira Ryman about a recently published review article that explores…

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MDS Podcast Disentangling the Cognitive Effects of Acute Levodopa in Parkinson’s Disease

In this episode, Dr. Joseph Seemiller and Dr. Kelly Mills discuss the changes in cognitive performance in the OFF and ON states during an acute levodopa challenge in a large cohort of patients with Parkinson’s disease. Their study’s findings suggest divergent complex changes in processing speed and executive function. Read the article »

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MDS Podcast Exploring postural control in functional motor disorders using virtual reality

In this episode, Drs. Gandolfi and Tinazzi discuss how virtual reality can be used as a therapeutic tool to modulate attention in patients with functional motor disorder, while measuring postural control. Read the article »

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MDS Podcast Is levodopa disease modifying? Long-term LEAP study follow-up

Prof. Rob de Bie joins Dr. Sara Schaefer to discuss the 5-year follow up extension to the Levodopa in Early Parkinson’s disease (LEAP) study, including the results and indications for practice. Journal CME is available until July 01, 2025 Read the article.

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MDS Podcast A post-hoc analysis of the Prasinezumab trial in early Parkinson’s disease

Dr. Gennaro Pagano discusses the findings of the post-hoc analysis of the PASADENA trial, a study using the monoclonal antibody Prasinezumab directed at aggregated α-synuclein, where motor progression trajectories differed between active and placebo groups. Read article »

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MDS Podcast Do subjective cognitive complaints predict future incident cognitive impairment in people with Parkinson’s disease?

Dr. Eduardo Fernández and Dr. Daniel Weintraub discuss whether subjective cognitive complaints can predict future incident cognitive impairment and other questions related to early cognitive impairment in people with Parkinson’s disease, referencing Dr. Weintraub’s recent article, «Association between subjective cognitive complaints and incident functional impairment in Parkinson’s disease» published in Movement Disorders. Read article »

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MDS Podcast Lixisenatide in Parkinson’s: A Diabetes Drug to Slow Disease Progression?

Dr. Michele Matarazzo interviews Dr. Olivier Rascol on the results of the clinical trial recently published in the New England Journal of Medicine. Tune in to learn about the mechanisms of action and potential of lixisenatide and other GLP-1 receptor agonists in impacting the progression of Parkinson’s disease. Read the article »

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MDS Podcast Hot Topic: Limitations of phenomenology in functional movement disorders: what can we learn?

In this Hot Topic episode, Dr. Sarah Lidstone moderates a discussion with Dr. Mark Hallett and Prof. Mark Edwards on the limitations of phenomenology in movement disorders. Drawn from a recent viewpoint by Prof. Edwards and using functional movement disorder as an example, they discuss the benefits and drawbacks of a phenotype equaling disease paradigm,…

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