Podcast: MDS PODCAST: Defining Parkinson's disease

MDS Podcast Is levodopa disease modifying? Long-term LEAP study follow-up

Prof. Rob de Bie joins Dr. Sara Schaefer to discuss the 5-year follow up extension to the Levodopa in Early Parkinson’s disease (LEAP) study, including the results and indications for practice. Journal CME is available until July 01, 2025 Read the article.

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MDS Podcast A post-hoc analysis of the Prasinezumab trial in early Parkinson’s disease

Dr. Gennaro Pagano discusses the findings of the post-hoc analysis of the PASADENA trial, a study using the monoclonal antibody Prasinezumab directed at aggregated α-synuclein, where motor progression trajectories differed between active and placebo groups. Read article »

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MDS Podcast Do subjective cognitive complaints predict future incident cognitive impairment in people with Parkinson’s disease?

Dr. Eduardo Fernández and Dr. Daniel Weintraub discuss whether subjective cognitive complaints can predict future incident cognitive impairment and other questions related to early cognitive impairment in people with Parkinson’s disease, referencing Dr. Weintraub’s recent article, «Association between subjective cognitive complaints and incident functional impairment in Parkinson’s disease» published in Movement Disorders. Read article »

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MDS Podcast Lixisenatide in Parkinson’s: A Diabetes Drug to Slow Disease Progression?

Dr. Michele Matarazzo interviews Dr. Olivier Rascol on the results of the clinical trial recently published in the New England Journal of Medicine. Tune in to learn about the mechanisms of action and potential of lixisenatide and other GLP-1 receptor agonists in impacting the progression of Parkinson’s disease. Read the article »

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MDS Podcast Hot Topic: Limitations of phenomenology in functional movement disorders: what can we learn?

In this Hot Topic episode, Dr. Sarah Lidstone moderates a discussion with Dr. Mark Hallett and Prof. Mark Edwards on the limitations of phenomenology in movement disorders. Drawn from a recent viewpoint by Prof. Edwards and using functional movement disorder as an example, they discuss the benefits and drawbacks of a phenotype equaling disease paradigm,…

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MDS Podcast Understanding corticobasal syndrome: Clinical and neuroimaging characteristics to unlock the underlying pathology

Dr. Michele Matarazzo interviews Dr. Jacy Parmera about her recently published article on the clinical and neuroimaging characteristics of patients with corticobasal syndrome, with a focus on the potential correlation with the underlying neuropathological causes. Read the article »

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MDS Podcast Chorea Series: Exploring medical and surgical management for chorea

Profs. Elena Moro and Ruth Walker discuss the management of chorea, including when this is appropriate. They focus on Huntington’s disease and the role of deep brain stimulation and other surgical interventions, in addition to medical management.

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MDS Podcast CSF1R-related disorder in China

Dr. Sara Schaefer speaks with Doctors Xiaojun Huang and Jingying Wu about the phenotypic and genotypic spectrum of CSF1R-related disorder in a Chinese population, including unique clinical and radiographic characteristics. Journal CME is available until May 21, 2025 Read the article.

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MDS Podcast Chorea Series: Approach to patients with acquired choreas

Dr. Ruth Walker and Dr. Molly Cincotta discuss causes of acquired chorea and approach to the work-up of a patient with an acquired chorea.

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