Dr. Sarah Camargos is joined by Dr. Rajeev Kumar to explore early research on targeting neuroinflammation in Huntington’s disease. Dr. Kumar delves into the intricacies of the complement cascade, highlighting the pivotal role of C1q as the recognition molecule at the top of this immune system chain reaction and how ANX005 aims to prevent the…

Ms. Nicole Duff and Prof. Hae-Young Hawong discuss the benefits of Argentine tango in the rehabilitation of person’s with Parkinson disease. The motor, non-motor, social, and quality of life gains are all explored; in addition to, the neuro-anatomical, neurophysiological and neuroplastic benefits. Prof. Hawong also describes the very successful and passion-based Argentine tango program she…

Dr. Norihito Uemura joins Prof. Tiago Outeiro to discuss perampanel, an AMPA receptor antagonist, and how it has been shown to block alpha-synuclein propagation and neurodegeneration in a mouse model of Lewy body disease. Dr. Uemura explains the mechanistic findings of transsynaptic propagation and the study limitations pertaining to mouse behavior. They also discuss perampanel’s…

Ms. Nicole Duff and Dr. Marjan Meinders discuss end of life preferences of people with Parkinson’s disease. Together they discuss the ways that end-of-life records could be sourced, as well as what information could be found in the end-of-life record. They further dive into the differences between specific European countries and the reasons around the…

Dr. Connie Marras discusses with Dr. Sara Schaefer her recent study in Movement Disorders Clinical Practice exploring the perspective of Persons with Parkinson’s disease on the definition of quality of life. Read the article.

Myths and misconceptions related to the surgical risks of deep brain stimulation (DBS) procedures remain common despite many years of evidence demonstrating its relative safety. This leads to both patient and provider fear in referring eligible patients for consideration of a potentially life-altering therapy for symptom management in many movement disorders. Dr. Mitra Afshari speaks…

For many years ataxias, especially the genetic forms, were considered untreatable diseases. In this episode Dr. Orlando Barsottini and Dr. Liana Rosenthal discuss the new advances in the treatment of ataxias and perspectives for the future.

Prodromal autonomic dysfunction has emerged as an important area of research in understanding Lewy body diseases, including Parkinson’s disease, and dementia with Lewy bodies. Dr. Michelle Matarazzo sits down with three experts in the field, Dr. Abhimanyu Mahajan, Dr. Alison Yarnall, and Dr. David Goldstein to discuss the current evidence behind various disturbances and how…

Genetic ataxias have many non-motor features, such as fatigue, sleep disorders, and cognitive dysfunction. In this episode, Dr. Orlando Barsottini and Dr. Christofer Stephen discuss the most common non-motor symptoms and how to approach them.

Dr. Michele Matarazzo sits down with Dr. Rebecca Wallings to discuss  how two of the most important genetic forms for Parkinson’s disease, LRRK2 and GBA1, influence immune response to bacterial simulation. Their discussion highlights a potential link between genetics, environment, and inflammation in Parkinson’s disease. Journal CME is available until March 18, 2027 Read the…