1. Featured Article: Dual antiplatelet therapy pretreatment in intravenous thrombolysis for acute ischemic stroke2. What’s Trending: Recurrent glioblastoma treated with recombinant poliovirusDr. Dan Ackerman talks with Dr. Andrei Alexandrov about his paper on dual antiplatelet therapy pretreatment. In the second part of the podcast, Dr. Kait Nevel focuses her interview with Dr. Darrell Bigner on treatment for recurrent glioblastoma. DISCLOSURES: Dr. Alexandrov has served on a scientific advisory board and consulted for Cerevast Therapeutics, Inc.; has served on editorial boards for Cerebrovascular Diseases and Interventional Neurology; holds a patent, and receives associated license fee and royalty payments, for «Therapeutic Methods and Apparatus for Use of Sonication to Enhance Perfusion of Tissue” (US patent 6,733,450 – May 11, 2004); receives publishing royalties for Cerebrovascular Ultrasound in Stroke Prevention and Treatment (Futura / Blackwell Publishing. 2003.), Cerebrovascular Ultrasound in Stroke Prevention and Treatment (Oxford: Blackwell Publishing (in Chinese) 2007), Cerebrovascular Ultrasound in Stroke Prevention and Treatment (2nd Edition) (Oxford: Wiley-Blackwell Publishers. 2011); has served on speakers’ bureau for Genentech, Inc.; has received research support from Cerevast Therapeutics, Inc. and NINR (R01 pending); holds stock or stock options in Cerevast Therapeutics, Inc.; receives Board of Reagents compensation from Cerevast Therapeutics, Inc.; and serves as President-Elect for the American Society of Neuroimaging. All other participants report no disclosures.