1) Paraneoplastic isolated myelopathy and 2) Topic of the month: Unusual headache syndromes. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Drs. Erik Ensrud and Isabel Arrilaga-Romany interviews Dr. Sean Pittock about his paper on paraneoplastic isolated myelopathy. In the next segment, Dr. Stacey Clardy is reading our e-Pearl of the week about oy-sters in psychogenic non-epileptic seizure diagnosis. In the next part of the podcast Dr. Noah Kolb interviews Dr. Michael Sowell about secondary headaches to conclude this month’s theme about unusual headache syndromes. The participants had nothing to disclose except Drs. Pittock and Clardy.Dr. Pittock may accrue revenue for patents re: aquaporin-4 associated antibodies for diagnosis of neuromyelitis optica and aquaporin-4 autoantibody as a cancer marker; and has received research support from Alexion Pharmaceuticals, Inc. and the Guthy Jackson Charitable Foundation.Dr. Clardy serves on the editorial team for the Neurology® Resident and Fellow Section.