This Podcast for the Neurology Journal begins and closes with Dr. John H. Noseworthy, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Burns interview Drs. James Connor and Zachary Simmons about their paper on CSF biomarkers in ALS. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about early electrodiagnosis of Guillain-Barre syndrome. The podcast concludes where Dr. Eddie Patton interviews Dr. Susanne May about Spearman rank and Pearson correlation coefficients for the Lesson of the Week segment. The participants had nothing to disclose.