This Podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Ted Burns interviews Dr. Hans Dieter Katzberg about the AAN guidelines on treatment for muscle cramps. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about coat hanger sing in multiple sclerosis atrophy. In the next part of the podcast Dr. Beau Bruce interviews Dr. Robert Naismith for our Lesson of the Week about natalizumab (Tysabri). The participants had nothing to disclose except Drs. Burns and Katzberg. Dr. Burns receives a stipend as Podcast Editor for Neurology®, performs EMG studies in his neuromuscular practice (30% effort), and received compensation for a presentation on MG-QOL15, given to study investigators of eculizumab in myasthenia gravis.Dr. Katzberg has received funding for travel from the Muscular Dystrophy Association.