1) Fragile X premutation and 2) Topic of the month: Stroke and stroke care. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Brandy Matthews interviews Dr. Kim Cornish about her paper on markers of at-risk profiles associated with the fragile X premutation. In the next segment, Dr. Jennifer Fugate is reading our e-Pearl of the week about the «cookie test» for brachial plexus birth injury. In the next part of the podcast Dr. Brett Kissela interviews Dr. Bo Norrving about World Stroke Organization and state of stroke care around the world. Over the subsequent two weeks, Dr. Kissela will interview Drs. Mark Eckman and Tom Brott about other aspects of stroke and stroke care. The participants had nothing to disclose except Drs. Matthews, Fugate, and Kissela.Dr. Brandy Matthews receives research support from the NIH.Dr. Fugate serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Kissela has served on the scientific advisory board for for Allergan, Inc.; receives honoraria from Allergan, Inc; receives research support from the NIH; and gave expert testimony in medico legal cases related to stroke.