1) IV thrombolysis-treated ischemic stroke patients and 2) Topic of the month: Paraneoplastic syndromes in neurology. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Brett Kissela interviews Dr. Daniel Strbian about his paper on IV thrombolysis-treated ischemic stroke patients. Dr. Jennifer Fugate is reading our e-Pearl of the week about RRT autoregulation. In the next part of the podcast Dr. Chafic Karam interviews Dr. Josep Dalmau about common paraneoplastic syndromes causing central nervous system disorders. Over the following weeks, Dr. Karam will interview Dr. Dalmau about other paraneoplastic syndromes in neurology. All participants have disclosures.