1) Multiple cranial nerve impairment and 2) Topic of the month: Encephalopathy caused by systemic disease. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Stephen Donahue interviews Dr. Vincent Roubeau about his paper on multiple cranial nerve impairment. Dr. Chafic Karam is reading our e-Pearl of the week about neurosyphilis presenting as mesial temporal encephalitis. In the next part of the podcast Dr. Ted Burns interviews Drs. Steven Lewis and Allison Weathers about vitamin deficiency, infection and autoimmunity. The participants had nothing to disclose except Drs. Karam, Burns, Lewis and Weathers.Dr. Karam serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Burns serves as Podcast Editor for Neurology®; performs EMG studies in his neuromuscular practice (35% effort); and has received research support for consulting activities with CSL Behring and Alexion Pharmaceuticals.Dr. Lewis serves as CME Section Co-Editor for Neurology® and as Associate Editor for Continuum: Lifelong Learning in Neurology®; receives royalties for the books: Field Guide to the Neurologic Examination and Neurology for the Non-Neurologist and anticipates receiving royalties for the book: Neurologic Disorders due to Systemic Disease.Dr. Weathers receives honoraria as an AAN speaker.