1) Active multiple sclerosis and 2) Topic of the month: Headaches. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Michelle Johansen interviews Dr. Jack Ratchford about his paper on active multiple sclerosis. Dr. Jen Fugate is reading our e-Pearl of the week about nummular headache. In the next part of the podcast Dr. Jen Bickel interviews Dr. Gretchen Tietjen about the topic of women and migraine. The participants had nothing to disclose except Drs. Ratchford, Fugate and Tietjen.Dr. Ratchford serves as a consultant for Biogen Idec, Bristol-Myers Squibb and Diogenix, Inc.; and receives research support from Biogen Idec, Novartis, and Sun Pharmaceuticals. Dr. Fugate serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Tietjen serves as an Associate Editor of Headache; serves on the scientific advisory board for MAP Pharmaceuticals Inc. and holds stock options in Johnson & Johnson and Stryker.