1) HIV associated motor neuron disease: HERV-K activation and response to anti-retroviral therapy 2) e-Pearl topic: Ataxia with vitamin E deficiency3) Topic of the month: Neurology Today story on functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional careThis podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Ted Burns interviews Dr. Avindra Nath about his paper on human endogenous retrovirus-K in amyotrophic lateral sclerosis with HIV infection and response to treatment with anti-retroviral drugs. Dr. Sarah Wesley is reading our e-Pearl of the week about ataxia with vitamin E deficiency. In the next part of the podcast Dr. Andy Southerland interviews Prof. Heinrich Audebert about a Neurology Today story on the topic of functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care.DISCLOSURES: Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Nath serves as Associate Editor for Journal of Neurovirology; has patents for Tat as an immunogen, Diosgenin for Treatment of Neurodegenerative Diseases; Role of Kv Channels in Neuroregeneration and Protection; Role of Lominoid compounds as neuroprotective agents; Tat ELISA; and receives research support from the NIH.Dr. Wesley serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Southerland serves as Podcast Deputy Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: “Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;” and gave legal expert review. Prof. Audebert serves as Associate Editor for Frontiers of Teleneurology; is a consultant for Lundbeck Inc., Roche, Bayer Schering Pharma, Pfizer Inc; received speaker honoraria from Takeda Pharmaceutical Company Limited, Boehringer Ingelheim, Lundbeck Inc., Bayer Schering Pharma, UCB, Sanofi-aventis, Pfizer Inc, Bristol-Myers Squibb and EverNeuropharma; participated in an expert meeting launched by Lundbeck Inc. in order to estimate the target population for Desmoteplase; receives research support from the Technology Foundation Berlin and the Berlin Investment Bank with co-financing by the European Union, and Center for Stroke Research Berlin, funded by the German Federal Ministry of Education and Research.