The Human Optimization Project

Hosted ByMayo Clinic

Mayo Clinic Human Optimization Project
The bar for human performance is higher than it’s ever been. As a result, we all feel the need to do MORE. At the same time, we are becoming increasingly aware of the value of sleep, rest, recovery, and wellness. Accordingly, we also feel the need to do LESS. If you’re like most people, it can be challenging to reconcile this conflict of feeling the need to do MORE and LESS simultaneously, and that is likely contributing to high rates of burnout and decreased performance. So how do we reconcile these seemingly competing desires? That is where Human Optimization comes in. Human Optimization is the process of achieving more (however you define that for yourself) while simultaneously improving your wellness and well-being. Although it’s not easy, it’s certainly possible. Not only is it possible, but it is becoming increasingly essential. In this Mayo Clinic Talks Mini-Series, we are going to dive into the topic of Human Optimization and will focus on a few key areas including: exercise, nutrition, culture, emotional intelligence, and finding joy in all you do.

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Mayo Clinic Human Optimization Project 19: E19 Beyond Lifespan: The Pursuit of Healthspan and Vitality

2 de julio de 2025 casimedicos The Human Optimization Project 00:56:54 0 Comments

Host: Christopher L. Camp, M.D., Creator & Guide | Mayo Clinic Human Optimization Project

Guest: Sara L. Bonnes, M.D., M.S., Medical Director, Healthy Longevity Clinic | Mayo Clinic – Rochester, MN

 

There is increased attention being paid to the concept of longevity recently. People are living longer than they ever have, and the desire to continually extend our lifespan is at an all-time high. While much of the attention is being directed at how LONG we live, it is easy to overlook the importance of how WELL we live during those years. So how can we ensure that our years are not just long, but that they are healthy? How can we optimize both the QUANTITY, as well as the QUALITY of the years we have here on earth? To help us with this session, our expert is Dr. Sara Bonnes, the Medical Director of the Healthy Longevity Clinic at Mayo Clinic.

 

The three big questions for Dr. Bonnes are:

1. What is “longevity,” and how does focusing on healthspan differ from simply trying to live longer

2. What are the main areas in our lives that determine our “healthspan”?

3. How can the average person incorporate practical lifestyle changes to support both a longer life and better quality of life?

 

How to start a Mayo Clinic Human Optimization Project “Pod-Club”:
Step 1: Find 2-30 friends who want to get better
Step 2: Choose your episodes (can be focused on specific themes or random)
Step 3: Listen to/watch the episodes
Step 4: Meet with your group to work through the provided discussion questions in the PDF for each episode, and feel free to add your own!
Step 5: Celebrate the fact that you are turning passive knowledge into action!

 

Discussion Questions for this Episode:

  1. Dr. Bonnes highlights that while the average lifespan is increasing, our years lived in good health (i.e. healthspan) is shortening, with an average 9.6-year gap between lifespan and healthspan in the US. What are your personal aging goals? What does «living in good health» mean to you? 
  2. Only about 20% of our longevity is determined by genetics while 80% is influenced by our lifestyle choices. Does this understanding of personal decision-making empower or challenge your current approach to your health? 
  3. Dr. Bonnes discusses the «Blue Zones» and their common traits (social connections, daily movement, plant-based diet, limited distractions). Which of these Blue Zone traits do you already incorporate into your life? Which feel easiest to add or to strengthen? 
  4. The episode cautions against «fads» and «magic pills,» stressing the importance of evidence-based strategies. What criteria (e.g., human studies, multiple research teams, relevance to your population) do you use to determine the credibility and safety of health trends or supplements? Be honest here! 
  5. Dr. Bonnes asks, «How old do you feel?» and Dr. Camp mentions «old man noises» (grunting from movement, sighing with mild pain) as a sign of premature aging. Have you noticed signs that you might be aging unhealthily or prematurely? What changes seem doable to you to improve your health as you age? 
  6. The discussion encourages focusing on short-term, achievable goals that improve your quality of life now, rather than solely on distant longevity targets. What’s one small, practical lifestyle change you could make this week that would bring you immediate benefits and contribute to your long-term healthspan? 
  7. The podcast lists key areas to eliminate (tobacco, toxins, excessive alcohol, processed foods, over-reliance on electronics) and to add (movement, whole foods, sleep, positive attitude, social connection). Select one item from each list that could bring you the most benefit, and share that with your pod club. Commit to eliminating the item you selected and adding the item you selected. You might note how you feel each day to document any noticeable changes! 
  8. Dr. Bonnes stresses the importance of dental health and vaccinations as often-overlooked contributors to longevity. How regularly do you prioritize these and other aspects of preventive care? What changes, if any, do you want to make and why? 

 

Learn more about the Human Optimization Project at: https://ce.mayo.edu/optimize
X: @MayoHumanOpProj
Instagram: @MayoHumanOpProj
YouTube:  The Human Optimization Project – YouTube
Email: optimize@mayo.edu

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